Hopeful Heart Trial

(PI: BRUCE ROLLMAN)

Blended Collaborative Care for Heart Failure and Co-Morbid Depression

This randomized clinical trial of patients with heart failure and comorbid depression showed that telephone-delivered blended collaborative care improved health-related quality of life (mHRQOL) and mood more than usual care, and mood more than collaborative care for heart failure alone.

Rollman BL, Anderson AM, Rothenberger SD, Abebe KZ, Ramani R, Muldoon MF, Jakicic JM, Herbeck Belnap B, Karp JF. Efficacy of Blended Collaborative Care for Patients With Heart Failure and Comorbid Depression: A Randomized Clinical Trial. JAMA Intern Med. 2021 Aug 30. doi: 10.1001/jamainternmed.2021.4978. Epub ahead of print. PMID: 34459842.

The Biostatistics Core was responsible for providing statistical and design expertise, and the development and execution of statistical analysis plans.